From a Managers perspective, am questioning whether embedded scripting is really the only benefit that IronPython/IronRuby offer. Running Django or Ruby On Rails on IronPython/IronRuby is surely just of technical interest.
Sure there are always edge-cases, i.e. a throwaway or trivial project being undertaken by a Ruby/Python expert that might need to access existing .NET libraries, but outside of that?
http://daringfireball.net/2010/04/iphone_agreement_bans_flash_compiler
See also post on MonoTouch forums... http://forums.monotouch.net/yaf_postst645.aspx
Need to target the full .NET Framework 4 because Log4Net has a dependency on System.Web.dll which is not included in the client profile.

Sikuli is at http://groups.csail.mit.edu/uid/sikuli/